Resident Evil 2 and Resident Evil 2 (Remake) Both the original and remade versions of the game get fun poked at them from time to time due to odd lines present in both (for example, the former's 'Wesker, YOU'RE pitiful!' and the latter's 'Wesker, you've become senile!'), but Chris bursting out laughing and Wesker's oddly disappointed-sounding response in the former is particularly infamous. Stop it! :(' Explanation The scene where Wesker reveals the Tyrant to Chris has risen in meme status in recent time, partly with the aid of a parody fan animation. It was so bad that it circled back around to So Bad, It's Good, and it became a source of comedy when juxtaposed with the game itself. It's considered universally to be one of the worst songs in video game history, and is frequently described as things like 'a mob of farting clowns', 'the theme of a depressed drunk guy stumbling down the street', or 'an angry trombone argument'.
He also doesn't care about anyone else but him.
After reading the journal, the zombified author bursts out of the closet right next to you (or before reading it, in the original game).
Explanation The last line from particularly infamous Apocalyptic Log from RE, documenting the writer's infection with the T-virus ending with his killing and eating his friend.